Phylogenetic analysis is a cornerstone of biology and bioinformatics. The programs are diverse and complex, the computations are long-running, and the datasets are often large. Many programs are standalone and many have proprietary input and output formats. This has created a very complex ecosystem that we must navigate when dealing with phylogenetic data, meaning that, often, the simplest strategy is to use combinations of tools to load, convert, and save the results of analyses in order to be able to use them in different packages. In this recipe, we'll look at dealing with phylogenetic tree data in R. To date, R support for the wide range of tree formats is restricted, but a few core packages have sufficient standardized objects such that workflows can focus on a few types and conversion to those types is streamlined...
R Bioinformatics Cookbook
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R Bioinformatics Cookbook
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Overview of this book
Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples.
This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse.
By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data.
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Current Title:
R Bioinformatics Cookbook
Table of Contents (13 chapters)
Preface
Free Chapter
Performing Quantitative RNAseq
Finding Genetic Variants with HTS Data
Searching Genes and Proteins for Domains and Motifs
Phylogenetic Analysis and Visualization
Metagenomics
Proteomics from Spectrum to Annotation
Producing Publication and Web-Ready Visualizations
Working with Databases and Remote Data Sources
Useful Statistical and Machine Learning Methods
Programming with Tidyverse and Bioconductor
Building Objects and Packages for Code Reuse
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