Book Image

R Bioinformatics Cookbook

By : Dan MacLean
Book Image

R Bioinformatics Cookbook

By: Dan MacLean

Overview of this book

Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples. This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse. By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data.
Table of Contents (13 chapters)

Visualizing trees of many genes quickly with ggtree

Once you have computed a tree, the first thing you will want to do with it is take a look. That's possible in many programs, but R has an extremely powerful, flexible, and fast system in the form of the ggtree package. In this recipe, we'll learn how to get data into ggtree and re-layout, highlight, and annotate tree images in just a few commands.

Getting ready

You'll need the ggplot2, ggtree, and ape packages. You'll also require the itol.nwk file from the datasets/ch4 folder of this book's repository, which is a Newick tree of 191 species from the Interactive Tree of Life online tool's public dataset.

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