The sequences of genes, proteins, and entire genomes hold clues to their function. Repeated subsequences or sequences with a strong similarity to each other can be clues to things such as evolutionary conservation or functional relatedness. As such, sequence analysis for motifs and domains are core techniques in bioinformatics. Bioconductor contains many useful packages for analyzing genes, proteins, and genomes. In this chapter, you will learn how to use Bioconductor to analyze sequences for features of functional interest, such as de novo DNA motifs and known domains from widely used databases. You'll learn about some packages for kernel-based machine learning to find protein sequence features. You will also learn some large-scale alignment techniques for very many, or very long sequences. You will use Bioconductor and...
R Bioinformatics Cookbook
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R Bioinformatics Cookbook
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Overview of this book
Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples.
This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse.
By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data.
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R Bioinformatics Cookbook
Table of Contents (13 chapters)
Preface
Free Chapter
Performing Quantitative RNAseq
Finding Genetic Variants with HTS Data
Searching Genes and Proteins for Domains and Motifs
Phylogenetic Analysis and Visualization
Metagenomics
Proteomics from Spectrum to Annotation
Producing Publication and Web-Ready Visualizations
Working with Databases and Remote Data Sources
Useful Statistical and Machine Learning Methods
Programming with Tidyverse and Bioconductor
Building Objects and Packages for Code Reuse
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