When we refer to a Citrix architecture, we usually mean an infrastructure located in the same area or building. In some cases, especially in the presence of very large organizations, you could have a central infrastructure used by many remote locations, also known as branch offices. In this case, the native optimization of the ICA protocol would not be sufficient for the performance needs of remote users without performance issues, because of the WAN bandwidth being constricted. In this scenario, Citrix presents CloudBridge, which is a WAN optimizer, developed for such situations. It comes in different editions: physical network devices and virtual appliances. In this chapter, we are going to discuss this second solution.