You can change the target datastore of an Ongoing replication by reconfiguring the replication. Doing so will result in the deletion of the files from the current destination datastore, and an initial full sync will be done again to the new target datastore location.
The following procedure will guide you through the steps required to change the target datastore of an ongoing replication:
Connect to the vCenter Server and navigate to the inventory home.
Click on vSphere Replication to bring up the vSphere Replication home.
Click on Monitor to go to the monitor with the vSphere Replication sub-tab selected.
In the left-hand pane, you will find both Outgoing Replications and Incoming Replications selected. Make an appropriate selection depending on whether you are at the local or the remote vCenter Server.
Right-click on the desired replication and click on Reconfigure to start the reconfiguration wizard.
Select a replication server to handle the traffic. In this case...