Book Image

Deep Learning for Genomics

By : Upendra Kumar Devisetty
Book Image

Deep Learning for Genomics

By: Upendra Kumar Devisetty

Overview of this book

Deep learning has shown remarkable promise in the field of genomics; however, there is a lack of a skilled deep learning workforce in this discipline. This book will help researchers and data scientists to stand out from the rest of the crowd and solve real-world problems in genomics by developing the necessary skill set. Starting with an introduction to the essential concepts, this book highlights the power of deep learning in handling big data in genomics. First, you’ll learn about conventional genomics analysis, then transition to state-of-the-art machine learning-based genomics applications, and finally dive into deep learning approaches for genomics. The book covers all of the important deep learning algorithms commonly used by the research community and goes into the details of what they are, how they work, and their practical applications in genomics. The book dedicates an entire section to operationalizing deep learning models, which will provide the necessary hands-on tutorials for researchers and any deep learning practitioners to build, tune, interpret, deploy, evaluate, and monitor deep learning models from genomics big data sets. By the end of this book, you’ll have learned about the challenges, best practices, and pitfalls of deep learning for genomics.
Table of Contents (18 chapters)
1
Part 1 – Machine Learning in Genomics
5
Part 2 – Deep Learning for Genomic Applications
11
Part 3 – Operationalizing models

Anatomy of deep neural networks

Neural networks are a collection of neurons that are interconnected with each other through various layers that can learn the mapping between the inputs and the outputs with the provided training data. Neural networks model complex patterns in datasets where traditional ML algorithms fail. They use multiple hidden layers and non-linear activation functions. The concept of a neural network was put first forth by Warren McCullough and Walter Pitts in 1944, and they describe a neural network as the collection of connected nodes (https://www.cambridge.org/core/journals/journal-of-symbolic-logic/article/abs/warren-s-mcculloch-and-walter-pitts-a-logical-calculus-of-the-ideas-immanent-in-nervous-activity-bulletin-of-mathematical-biophysics-vol-5-1943-pp-115133/7DFDC43EC1E5BD05E9DA85E1C41A01BD). Here, nodes represent artificial neurons, which are the functional units of neural networks which we will discuss in the following section.

The fundamental unit of...