Book Image

Deep Learning for Genomics

By : Upendra Kumar Devisetty
Book Image

Deep Learning for Genomics

By: Upendra Kumar Devisetty

Overview of this book

Deep learning has shown remarkable promise in the field of genomics; however, there is a lack of a skilled deep learning workforce in this discipline. This book will help researchers and data scientists to stand out from the rest of the crowd and solve real-world problems in genomics by developing the necessary skill set. Starting with an introduction to the essential concepts, this book highlights the power of deep learning in handling big data in genomics. First, you’ll learn about conventional genomics analysis, then transition to state-of-the-art machine learning-based genomics applications, and finally dive into deep learning approaches for genomics. The book covers all of the important deep learning algorithms commonly used by the research community and goes into the details of what they are, how they work, and their practical applications in genomics. The book dedicates an entire section to operationalizing deep learning models, which will provide the necessary hands-on tutorials for researchers and any deep learning practitioners to build, tune, interpret, deploy, evaluate, and monitor deep learning models from genomics big data sets. By the end of this book, you’ll have learned about the challenges, best practices, and pitfalls of deep learning for genomics.
Table of Contents (18 chapters)
1
Part 1 – Machine Learning in Genomics
5
Part 2 – Deep Learning for Genomic Applications
11
Part 3 – Operationalizing models

DNNs for genomics

The field of genomics has benefitted primarily due to the technological advancements in NGS, which can generate genomics data at a low cost and scale. This opened opportunities for many areas of science, such as bioinformatics and ML. Bioinformatics, the field of computational algorithms used to process biological data, was hugely successful in genomics, enabling rules to mine insights from the data. ML methodologies have a huge influence on genomics for solving some complex biological problems such as gene signatures, functional genomics, gene interactions, and so on. However, the current advances in genomics technologies, coupled with ever-growing genomics data, have created lots of new challenges that require highly accurate and sophisticated algorithms.

DL, a component of ML, has made significant strides in the areas of speech recognition, computer vision, machine translation, NLP, and so on. Because of DL’s ability to solve complex tasks with high accuracy...