Let's start with the easiest way to speed up your workflow: keyboard shortcuts. Using keyboard shortcuts in Sandbox is just the same as using them in any of your favorite games. Have you ever played a strategy game or an MMO without using shortcuts altogether? It is certainly possible to just use the mouse and none of the many shortcuts available when you guide your character through the depth of a virtual dungeon, but would you do it? Probably not, since using shortcuts is much less exhausting and you can use them without looking at the screen and constantly travelling with your mouse to the various buttons on the user interface.
This is the same for using Sandbox. There are plenty of shortcuts for all kinds of features, and by making use of those, you will not only increase the speed at which you work, but also work in a more relaxed manner because you reduce the amount of mouse movement needed.