As of writing this guide, the vCenter Server appliance is not commonly used with VMware Horizon View. The main downside to the appliance is the inability to collocate the View Composer with the vCenter as the View Composer requires a Windows Server. As a consequence of that the main benefit of one reduced Windows Server license isn't fulfilled when using the appliance with Horizon View. VMware does support using the vCenter appliance with Horizon View, but with using a standalone View Composer Server.
Tip
For information on upgrading the vCenter Server Appliance, please consult VMware's documentation:
https://blogs.vmware.com/vsphere/2015/09/updating-vcenter-server-appliance-6-0-to-update-1.html
For upgrading from the vCenter Appliance 5.5 to 6.0 please read the following documentation: