Virtual desktops, what a great idea! VDI offers central management of your desktops. On paper, this is a perfect solution. In reality, it's still a great solution but only for certain use cases. Very few enterprises can use VDI for their whole user base, but where it's possible it can be a great solution. The holy grail in VDI is to have only one Golden Image, shared by all users. User-unique changes are stored as delta changes. Hardly anyone manages to get down to only one Golden Image. One thing you want to make sure though, is that the application entitlement is not forcing you to manage many different Golden Images.
Furthermore, application entitlement shouldn't change the user-unique delta disk. If you achieve this, you will require much less expensive SAN storage, and by minimizing your SAN investment, your VDI ROI (return on investment) and TCO (total cost of ownership) calculation will become much more appealing...