Rtree
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This is a Python wrapper of libspatialindex that provides advanced spatial indexing features
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http://toblerity.org/rtree
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rasterio
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This is a Mapbox creation that aims at working with rasters in an easier manner
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https://github.com/mapbox/rasterio
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Fiona
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This focuses on reading and writing data in the standard Python I/O style
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http://toblerity.org/fiona
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geopy
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This helps geocoding in Python
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http://www.geopy.org
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PyQGIS
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This is the Python interface to QGIS (formerly known as Quantum GIS) that helps extend QGIS and more
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http://pythongisbook.com
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GeoPandas
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This is an extension of the pandas library and handles geospatial database
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http://geopandas.org/
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MapFish
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This is Python's geospatial web framework
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http://mapfish.org
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PyWPS
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This client interacts with various open geospatial standard services
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http://pywps.wald.intevation.org
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pycsw
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This provides a metadata catalog interface
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http://pycsw.org
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GeoNode
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This provides Python geospatial content management for the Web and is built on the Django web framework and GeoServer
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http://geonode.org
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mapnik
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This is a map visualization library to create maps for web tile cache
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http://mapnik.org
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cartopy
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This is mapping made easy in Python-shapely
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http://scitools.org.uk/cartopy
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Kartograph
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This creates SVG maps or web maps
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http://kartograph.org
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basemap
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This is an extension of matplotlib in combination with descartes
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http://matplotlib.org/basemap
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SciPy
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This is a collection of Python libraries for scientific data analysis that are bundled or available as individual installations
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http://www.scipy.org
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GeoAlchemy
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This is a spatial extension to SQLAlchemy that works with the spatial database PostGIS
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http://geoalchemy.org
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pyspatialite
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This helps you work with spatialite databases of geospatial data
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https://pypi.python.org/pypi/pyspatialite
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gpxpy
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This helps when working with GPS data in the standard GPX format in a Python - friendly format
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http://www.trackprofiler.com/gpxpy/index.html
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ShaPy
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This is a pure Python version of Shapely with no dependencies
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https://github.com/karimbahgat/Shapy
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pyshp
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This reads and writes Shapefiles in pure Python
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https://github.com/GeospatialPython/pyshp
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TileCache
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This is an implementation of a WMS-C (catalog) Tile Mapping Server (TMS) server
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http://tilecache.org
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TileStache
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This is a Python-based server application that can serve up map tiles based on rendered geographic data
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http://www.tilestache.org
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FeatureServer
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This is a restful feature service to easily get, edit, delete, and update features over the Web with the help of HTTP
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http://featureserver.org
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GeoScript
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This is an implementation of Python, giving spatial analysis functionality to other scripting languages and Python is one of them; it is similar to Shapely
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http://www.geoscript.org
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karta
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This is a Leatherman for geographic analyses
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http://ironicmtn.com/karta
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