In addition to traditional 3D modeling software like Blender (and ZBrush, 3D Studio Max, Maya, and so on) there is a new generation of 3D design apps that let you to directly create inside VR. After all, it's pretty awkward trying to use an inherently 2D desktop screen with a 2D mouse to form, sculpt, assemble, and manipulate 3D models. If only it could be more like real-life sculpture and construction. So, why not just do it directly in 3D? In VR!
Like other digital platforms, we can categorize VR apps into ones that present an experience, ones where you interact to engage with the environment, and ones where you actually create content, for yourself or for sharing. An example of the latter and one of the first to be widely successful is Google Tilt Brush (https://www.tiltbrush.com/) where you paint in 3D. This is one of my favorite go-to apps when introducing VR to family and friends. Tilt Brush lets you paint in 3D in virtual reality.
Other VR 3D with sculpting...