Book Image

R Bioinformatics Cookbook

By : Dan MacLean
Book Image

R Bioinformatics Cookbook

By: Dan MacLean

Overview of this book

Handling biological data effectively requires an in-depth knowledge of machine learning techniques and computational skills, along with an understanding of how to use tools such as edgeR and DESeq. With the R Bioinformatics Cookbook, you’ll explore all this and more, tackling common and not-so-common challenges in the bioinformatics domain using real-world examples. This book will use a recipe-based approach to show you how to perform practical research and analysis in computational biology with R. You will learn how to effectively analyze your data with the latest tools in Bioconductor, ggplot, and tidyverse. The book will guide you through the essential tools in Bioconductor to help you understand and carry out protocols in RNAseq, phylogenetics, genomics, and sequence analysis. As you progress, you will get up to speed with how machine learning techniques can be used in the bioinformatics domain. You will gradually develop key computational skills such as creating reusable workflows in R Markdown and packages for code reuse. By the end of this book, you’ll have gained a solid understanding of the most important and widely used techniques in bioinformatic analysis and the tools you need to work with real biological data.
Table of Contents (13 chapters)

Learning groupings within data and classifying with kNN

The k-Nearest Neighbors (kNN) algorithm is a supervised learning algorithm that, given a data point, will try to classify it based on its similarity to a set of training examples of known classes. In this recipe, we'll look at taking a dataset, dividing it into a test and train set, and predicting the test classes from a model built on the training set. These sorts of approaches are widely applicable in bioinformatics and can be invaluable in clustering when we have some known examples of our target classes.

Getting ready

For this recipe, we'll need a few new packages: caret, class, dplyr, and magrittr. As a dataset, we will use the built-in iris dataset.

...