One of the fundamental assumptions in regression approach is that the target variance is not correlated with either independent (attributes) or dependent (target) variables. An example where this assumption might break is counting data, which is generally described by Poisson distribution. For Poisson distribution, the variance is proportional to the expected value, and the higher values can contribute more to the final variance of the weights.
While heteroscedasticity may or may not significantly skew the resulting weights, one practical way to compensate for heteroscedasticity is to perform a log transformation, which will compensate for it in the case of Poisson distribution:
Some other (parametrized) transformations are the Box-Cox transformation:
Here, 
is a parameter (the log transformation is a partial case, where 
) and Tuckey's lambda transformation (for attributes between 0 and 1):
These compensate for Poisson binomial distributed attributes or the estimates of the...