You can change the target datastore of an ongoing replication by reconfiguring the replication. Doing so will result in the deletion of the files from the current destination datastore, and an initial full sync will be performed again to the new target datastore location.
The following procedure will guide you through the steps required to change the target datastore of an ongoing replication:
Connect to the vCenter Server and navigate to the inventory home page.
Click on vSphere Replication to bring up the vSphere Replication home page.
Click on Monitor to go to the monitor tab with the vSphere Replication subtab selected.
In the left pane, you will find both Outgoing Replications and Incoming Replications as selected. Make an appropriate selection depending on whether you are at the local or the remote vCenter Server.
Select the replication and click on the Reconfigure option in the Actions menu to start the reconfiguration wizard.
Select a replication server to...